This effect is most likely mediated by presynaptic GABA A receptors, however the exact location of these receptors is not known. The Journal of Physiology. While these results were observed in GABAergic neurons of the grey matter, it raises the question whether presynaptic GABA synthesis may similarly be elevated following white matter injury events. At an early developmental stage, GABA acts in an excitatory manner and is implicated in many processes of neurogenesis, including neuronal proliferation, migration, differentiation, and preliminary circuit-building, as well as the development of critical periods. The mechanism also appears to be PKC-mediated, as administration of staurosporine abolished the observed neuroprotection.
Brain Pathology Zurich, Switzerland Apr; 18 no.
Granny HD VPorn
GABA and Schizophrenia A substantial body of evidence points to developmental abnormalities as a crucial part of the etiology of schizophrenia. The subpallium which gives rise to GABAergic neurons also generates oligodendrocytes that migrate in a similarly tangential path to the cortex Marin and Rubenstein GABA in neuronal proliferation and migration Studies have shown GABA to have a variable trophic effect in different proliferative zones of the developing embryonic cortex, and it appears to play a role in the proliferation of neuronal progenitor cells Wang and Kriegstein ; Jovanovic and Thomson Increased inhibitory activity at GABA A receptors appears to have a neuroprotective role in transient ischemia whereas tonic inhibitory activity at extrasynaptic GABA A receptors may play a detrimental role in stroke pathology. The authors propose that decreased reelin expression may decrease the overall number of GABAergic axon terminals by decreasing the overall number of dendritic spines, and in this way explain the downregulation of GAD67 Costa et al. Studies have shown GABA to have a variable trophic effect in different proliferative zones of the developing embryonic cortex, and it appears to play a role in the proliferation of neuronal progenitor cells Wang and Kriegstein ; Jovanovic and Thomson The authors suggest that tonic inhibition may be a novel mechanism by which TBI contributes to functional impairment, notably loss of memory and cognitive function Mtchedlishvili et al.